Toxic effects of chlorinated cake flour in rats
作者:
H. M. Cunningham,
G. A. Lawrence,
L. Tryphonas,
期刊:
Journal of Toxicology and Environmental Health
(Taylor Available online 1977)
卷期:
Volume 2,
issue 5
页码: 1161-1171
ISSN:0098-4108
年代: 1977
DOI:10.1080/15287397709529514
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
Four experiments were conducted using weanling Wistar rats to determine whether chlorinated cake flour or its constituents were toxic. Levels of 0.2 and 1.0% chlorine added to unbleached cake flour significantly (p <0.01) reduced growth rate by 20.7 and 85.2% and increased liver weight relative to body weight by 16.7 and 25.3%, respectively. Lipids extracted from flour chlorinated at the same levels had similar effects. Rat chow diets containing 0.2 and 0.6% chlorine in the form of chlorinated wheat gluten reduced growth rate and increased liver weight as a percentage of body weight. A rat chow diet containing 0.2% chlorine as chlorinated flour lipids increased absolute liver weight by 40%, kidney by 20%, and heart by 10% compared to pair‐fed controls.
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