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Methylthiomethyl, a new carboxyl protecting group in peptide synthesis

 

作者: Arnaldo Dossena,   Gerardo Palla,   Rosangela Marchelli,   Tiziana Lodi,  

 

期刊: International Journal of Peptide and Protein Research  （WILEY Available online 1984）
卷期: Volume 23, issue 2  

页码: 198-202

 

ISSN:0367-8377

 

年代: 1984

 

DOI:10.1111/j.1399-3011.1984.tb02710.x

 

出版商: Blackwell Publishing Ltd

 

关键词: t‐butyl bromide;carboxyl protection;deblocking;dimethyl sulphoxide;methylthiomethyl group

 

数据来源: WILEY

 

摘要:

Nα‐protected amino acid methylthiomethyl esters (MTM) were obtained in good yields under mild conditions using the «ButBr/Me2SO» reagent. Selective removal of theN‐protecting group was achieved in HCl/anhydrous ethyl ether and the MTM ester hydrochlorides were successfully used in the synthesis of dipe

 

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