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Dietary sucrose, glucose, fructose, and starches affect colonic functions in rats
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Dietary sucrose, glucose, fructose, and starches affect colonic functions in rats
作者:
CaderniGiovanna,
LuceriCristina,
LancioniLorella,
DolaraPiero,
期刊:
Nutrition and Cancer
(Taylor Available online 1996)
卷期:
Volume 25,
issue 2
页码: 179-186
ISSN:0163-5581
年代: 1996
DOI:10.1080/01635589609514440
出版商: Taylor&Francis Group
数据来源: Taylor
摘要:
AbstractTo study the effect of dietary sugars and starches on parameters linked to colon carcinogenesis, female Sprague‐Dawley rats were fed for one month five different diets containing sucrose, glucose, fructose, cornstarch, or Hylon 7, a starch with a high amylose content. After this period, colon proliferation, assessed by [3H]thymidine incorporation in vitro, was higher (p<0.05) in rats fed sucrose than in rats fed glucose, fructose, or cornstarch [labeling index was 7.17±0.75, 5.03±0.70, 4.55±0.72, 4.00±0.70, and 5.89±1.05 (SE) in sucrose, glucose, fructose, cornstarch, and Hylon 7 diets, respectively]. Cecal pH was lower in rats fed cornstarch and Hylon 7 than in rats fed sucrose, glucose, or fructose. Content of short‐chain fatty acids (SCFAs) in the cecum was higher in rats fed Hylon 7 than in those fed glucose and fructose. In conclusion, glucose and fructose, compared with sucrose, decrease mucosal proliferation and may be considered protective factors in colon carcinogenesis, although they do not affect SCFA production and cecal pH. On the contrary, Hylon 7 does not change mucosal proliferation but increases SCFAs and lowers cecal pH, two conditions associated with a lower risk of colon cancer.
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