Biologie testing of leachable aromatic compounds from denture base materials
作者:
LygreHenning,
MoeGrete,
SolheimEinar,
GjerdetNils Roar,
期刊:
Acta Odontologica Scandinavica
(Taylor Available online 1995)
卷期:
Volume 53,
issue 6
页码: 397-401
ISSN:0001-6357
年代: 1995
DOI:10.3109/00016359509006008
出版商: Taylor&Francis
关键词: Acrylic resins;biologic effects;cytotoxicity;denture bases;leaching
数据来源: Taylor
摘要:
The aromatic compounds phenyl benzoate (PB), phenyl salicylate (PS), and biphenyl (BP), which have previously been found to leach from poly(methyl methacrylate) denture base materials, were tested for cytotoxicity and biologic effects by L929 cells in culture. The octanol-water partition coefficient (logPow), a descriptor for the lipophilicity, was determined for the compounds. Cytotoxicity was evaluated by total cell growth and the plating efficiency test, and biologic effects by the total fatty acid composition of L929 cells. The commonly used tests, total cell growth and plating efficiency, did not show any significant changes of the cells due to the compounds. On the other hand, BP and PS, in particular, induced changes in the total fatty acid composition of L929 cells. The problem of bioavailability of aromatic compounds in cell culture assays and the relation to lipophilicity was addressed.
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