&bgr;-Amyloid in Alzheimer's DiseaseTherapeutic Implications
作者:
Harvey B. Pollard,
Eduardo Rojas,
Nelson Arispe,
期刊:
CNS Drugs
(ADIS Available online 1994)
卷期:
Volume 2,
issue 1
页码: 1-6
ISSN:1172-7047
年代: 1994
出版商: ADIS
数据来源: ADIS
摘要:
Recent evidence has been accumulating to suggest that the peptide &bgr;-amyloid may be implicated as a causative agent in Alzheimer's disease. This compound is known to accumulate in the cerebral plaques that are characteristic of the disease. Whether &bgr;-amyloid is toxicper seis yet to be established, but several options are available which may reduce the toxicity of the agent and, thus, have potential in the treatment of Alzheimer's disease.Prevention of the generation of &bgr;-amyloid from the amyloid precursor protein (APP) and inhibition of the possible neurotoxic effects of the compound are being explored. A recent finding that has gained much attention is that &bgr;-amyloid can form ion channels that are cation-specific. An increase in intracellular calcium levels can occur via these channels, which may be neurotoxic and cause inflammatory responses. The use of channel blocking agents, such as trometamol (tromethamine), may prevent neurotoxicity, while anti-inflammatory drugs may also prove to be useful therapeutic agents.
点击下载:
PDF
(2557KB)
返 回