EFFECTS of adrenalectomy on the 5-HT1Areceptor agonist 8-hydroxy-2-di-n-(propylamino)tetralin (8-OHDPAT)-and 2-deoxy-D-glucose (2-DG)-induced hyper-phagia were investigated in rats. Prior adrenalectomy completely inhibited 2-DG-induced hyperphagia, although it did not affect increases in food intake elicited by 8-OH-DPAT. These results suggest that 8-OH-DPAT-induced hyperphagia is independent of the adrenal hormone, corticosterone while 2-DG-induced hyperphagia is closely related to corticosterone.