Treatment of Advanced Gastric Cancer with a Modified Regimen of Etoposide/Leucovorin/5-Fluorouracil
作者:
JyeTzeon,
PaoSung,
KuenRuey,
FanSan,
HwaiCheng,
HsinChih,
MinPo,
期刊:
Cancer Investigation
(Taylor Available online 1996)
卷期:
Volume 14,
issue 3
页码: 197-201
ISSN:0735-7907
年代: 1996
DOI:10.3109/07357909609012139
出版商: Taylor&Francis
数据来源: Taylor
摘要:
The efficacy and toxicity of a combination of etoposide 100 mg/m2/day iv on day 2–4, leucovorin 300 mg/m2/day iv, and 5-FU 500 mg/m2day iv on day 1–5 every 4 weeks were assessed in 21 patients with advanced gastric cancer with measurable or evaluable diseases. Eight patients had an objective response, including 3 in CR. The overall response rate was 38.1% (95% CI 33.4–42.8%). Five of 8 patients who exhibited locally advanced and unresectable diseases had an objective response (2 CR, 3 PR). The response rate in patients with metastatic disease was 23.0% (95% CI 14.4–31.6%). The median progression-free interval and overall survival time were 7 and 10 months, respectively. The most frequent side effect was alopecia (Gr I/II 71.4%). No treatment-related death occurred. Modified ELF is a relatively effective and tolerable combination regimen for advanced gastric cancer and can be safely administered to elderly patients and patients with systemic diseases.
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