Lack of compensatory megakaryocytopoiesis in HIV‐1‐seropositive thrombocytopenic individuals compared with immune thrombocytopenic purpura patients
作者:
Giorgio Zauli,
Maria Re,
Luigi Gugliotta,
Giuseppe Visani,
Nicola Vianelli,
Giuliano Furlini,
Michele Placa,
期刊:
AIDS
(OVID Available online 1991)
卷期:
Volume 5,
issue 11
页码: 1345-1350
ISSN:0269-9370
年代: 1991
出版商: OVID
关键词: HIV;thrombocytopenia;megakaryocyte progenitors granulocyte/macrophage colony-stimulating factor;interleukin 1 and 6
数据来源: OVID
摘要:
In this study we demonstrate that HIV-1-seropositive thrombocytopenic individuals, in contrast with immune thrombocytopenic purpura (ITP) patients, fail to have a compensatory increase of megakaryocytopoiesis. Thein vitrogrowth of bone-marrow megakaryocyte progenitors (CFU-MK) and the production of granulocyte/macrophage colony-stimulating factor (GM-CSF), interleukin (IL)-1 and IL-6 by bone-marrow mononuclear adherent cells and peripheral blood (PB) light-density mononuclear cells were studied in 12 HIV-1-seropositive thromobocytopenic individuals with respect to 12 ITP patients and 15 normal controls. In HIV-1-seropositive thrombocytopenic individuals, CFU-MK size (number of megakaryocytes per colony) was similar to normal controls but significantly lower (P< 0.05) than in ITP patients. IL-1 and IL-6 production was similar in the three groups of subjects. On the other hand, GM-CSF production by bone-marrow mononuclear adherent cells in HIV-1-seropositive thrombocytopenic individuals was similar to normal controls but significantly (P< 0.05) lower than in ITP patients, whereas GM-CSF production by PB light-density mononuclear cells was markedly (P< 0.05) defective compared with both normal controls and ITP patients. The positive correlation between number and size of CFU-MK and production of GM-CSF by bone-marrow mononuclear adherent cells, observed in all three groups of subjects, demonstrates the central role of GM-CSF in the control of megakaryocytopoiesis.
点击下载:
PDF
(537KB)
返 回