Dissociation of Tracheobronchial and Cardiac Effects of Some Beta-adrenergic Stimulants
作者:
Llynda Hinds,
Ronald Katz,
期刊:
Anesthesiology
(OVID Available online 1971)
卷期:
Volume 34,
issue 5
页码: 445-449
ISSN:0003-3022
年代: 1971
出版商: OVID
关键词: Cardiac beta-adrenergic receptors;Tracheobronchial beta-adrenergic receptors;Cardiac arrhythmias;Bronchoconstrictors;Bronchodilators;Isoproterenol;Salbutamol;Terbutaline
数据来源: OVID
摘要:
The effects of three beta-adrenergic stimulating agents, isoproterenol, salbutamol, and terbutaline, were studied in the cat. In animals receiving halopropane, the dose of salbutamol or terbutaline necessary to produce ventricular arrhythmias was 100-500 times greater than the dose of isoproterenol needed. In cats receiving nitrous oxide, a dose of carbachol which increased airway pressure 50-135 per cent for a preset tidal volume was given. This action of carbachol was blocked by 2 µg/kg of salbutamol or terbutaline. The large differences between bronchodilating and arrhythmia-producing doses of salbutamol and terbutaline suggest that these agents might be of value in the treatment of bronchoconstriction in conscious and anesthetized patients.
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