首页   按字顺浏览 期刊浏览 卷期浏览 Dissociation of Tracheobronchial and Cardiac Effects of Some Beta-adrenergic Stimulants
Dissociation of Tracheobronchial and Cardiac Effects of Some Beta-adrenergic Stimulants

 

作者: Llynda Hinds,   Ronald Katz,  

 

期刊: Anesthesiology  (OVID Available online 1971)
卷期: Volume 34, issue 5  

页码: 445-449

 

ISSN:0003-3022

 

年代: 1971

 

出版商: OVID

 

关键词: Cardiac beta-adrenergic receptors;Tracheobronchial beta-adrenergic receptors;Cardiac arrhythmias;Bronchoconstrictors;Bronchodilators;Isoproterenol;Salbutamol;Terbutaline

 

数据来源: OVID

 

摘要:

The effects of three beta-adrenergic stimulating agents, isoproterenol, salbutamol, and terbutaline, were studied in the cat. In animals receiving halopropane, the dose of salbutamol or terbutaline necessary to produce ventricular arrhythmias was 100-500 times greater than the dose of isoproterenol needed. In cats receiving nitrous oxide, a dose of carbachol which increased airway pressure 50-135 per cent for a preset tidal volume was given. This action of carbachol was blocked by 2 µg/kg of salbutamol or terbutaline. The large differences between bronchodilating and arrhythmia-producing doses of salbutamol and terbutaline suggest that these agents might be of value in the treatment of bronchoconstriction in conscious and anesthetized patients.

 

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