Thymostimulin Administration Modulates Polymorph Metabolic Pathway in Patients with Chronic Obstructive Pulmonary Disease
作者:
TortorellaCosimo,
OttolenghiAnna,
MorettiAnna Maria,
JirilloEmilio,
AntonaciSalvatore,
期刊:
Immunopharmacology and Immunotoxicology
(Taylor Available online 1992)
卷期:
Volume 14,
issue 3
页码: 421-437
ISSN:0892-3973
年代: 1992
DOI:10.3109/08923979209005402
出版商: Taylor&Francis
数据来源: Taylor
摘要:
AbstractSeveral studies outline the imbalance of phagocyte functions in chronic obstructive pulmonary disease (COPD). In this regard, here, we have assessed either monocyte- and polymorphonuclear cell (PMN)-mediated chemotactic, phagocytic and killing capacities or PMN-triggered metabolic pathway in a group of COPD patients before and at different times after thymostimulin administration. Before therapy, an increase of O2-generation and a decrease of myeloperoxidase release were found in these individuals when compared to controls. Moreover, a reduction of either PMN-mediated chemotaxis and killing or monocyte chemotactic capacities was observed. By contrast, no differences were seen in terms of p-glucuronidase release, monocyte-mediated killing and PMN or monocyte phagocytic function. During a one-year monitoring following immunotherapy, O2- production and myeloperoxidase activity fell within normal values, while phagocyte functional capacities were unaffected by such a treatment. Furthermore, COPD subjects exhibited a significant improvement of their clinical status as assessed during a one-year follow-up.All together, these findings suggest a potential role for thymostimulin in the treatment of COPD patients.
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