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Comparison of Lymphocyte Reactivity in Patients with Cancer, Systemic Lupus Erythematosus and Renal Allografts

 

作者: Nicole Suciu-Foca,   Frederic P. Herter,   Joseph A. Buda,   Keith Reemtsma,  

 

期刊: Oncology  （Karger Available online 1975）
卷期: Volume 31, issue 3-4  

页码: 125-132

 

ISSN:0030-2414

 

年代: 1975

 

DOI:10.1159/000225015

 

出版商: S. Karger AG

 

关键词: Cancer;Systemic lupus erythematosus;Allograft recipients;Cellular immunity;Lymphocyte depressive factors

 

数据来源: Karger

 

摘要:

The PHA and MLC reactivity of lymphocytes from patients with cancer, SLE or renal allografts was comparatively tested in the presence of autologous and of normal homologous serum. Sera from patients with advanced cancer, active SLE or chronic allograft rejection strongly inhibited the MLC reactivity of autologous lymphocytes. It is suggested that serum inhibitory factors might be antibodies which are directed against modified antigenic determinants of the major histocompatibility complex, and are capable of blocking T lymphocyte receptors.

 

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