Pharmacokinetic Individualisation of Zidovudine TherapyCurrent State of Pharmacokinetic-Pharmacodynamic Relationships
作者:
Richard M.W. Hoetelmans,
David M. Burger,
Pieter L. Meenhorst,
Jos H. Beijnen,
期刊:
Clinical Pharmacokinetics
(ADIS Available online 1996)
卷期:
Volume 30,
issue 4
页码: 314-327
ISSN:0312-5963
年代: 1996
出版商: ADIS
数据来源: ADIS
摘要:
Zidovudine is the cornerstone of current antiretroviral treatment of human immunodeficiency virus (HIV) infection. Its use, however, frequently leads to adverse reactions, including myelosuppression. Zidovudine pharmacokinetics show large interindividual variation with indications of pharmacokinetic-pharmacodynamic relationships, but a clear therapeutic window has not yet been defined. Individualisation of zidovudine therapy with monitoring of drug concentrations might be desirable. This review considers (intracellular) monitoring of zidovudine and anabolites for individualisation of zidovudine therapy and the achievements in describing pharmacokinetic-pharmacodynamic relationships so far.
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