p53-related pathways and the molecular pathogenesis of melanoma
作者:
M R Hussein,
A K Haemel,
G S Wood,
期刊:
European Journal of Cancer Prevention
(OVID Available online 2003)
卷期:
Volume 12,
issue 2
页码: 93-100
ISSN:0959-8278
年代: 2003
出版商: OVID
关键词: Cutaneous malignant melanoma;p53;ultraviolet radiation;UV
数据来源: OVID
摘要:
Cutaneous malignant melanoma (CMM) is a life-threatening cancer that can have a poor prognosis with high metastatic potential. Its incidence is rapidly increasing worldwide. Its molecular alterations involve multiple pathways, including those related to p53. Since 1981, more than 380 papers containing the terms ‘p53 and melanoma’ as key words in the Abstract have been published in the literature. However, in spite of these extensive investigations, a review of p53 and associated genes in CMM is still lacking. To remedy this issue, this review seeks to provide a brief overview of p53 and discuss the genes targeted along its related pathways.
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