Reversal of Barter's Syndrome by Renal Transplantation in a Child with Focal, Segmental Glomerular Sclerosis
作者:
SANDRA BLETHEN,
JUDSON VAN WYK,
WILLIAM LORENTZ,
JOHN JENNETTE,
期刊:
The American Journal of the Medical Sciences
(OVID Available online 1985)
卷期:
Volume 289,
issue 1
页码: 31-36
ISSN:0002-9629
年代: 1985
出版商: OVID
关键词: Bartter's syndrome;Focal segmental glomerular sclerosis;Prostaglandins
数据来源: OVID
摘要:
A four-year-old girl with growth failure and clinical and laboratory evidence of Bartter's syndrome responded to indomethacin treatment with decreased urinary prostaglandin excretion, symptomatic and chemical improvement, and accelerated growth. Large doses of aspirin produced a comparable decrease in prostaglandin excretion but no improvement in any other metabolic abnormality thus suggesting that abnormalities in prostaglandins were the result rather than the cause of the electrolyte abnormalities. Progressive renal insufficiency while on indomethacin prompted a renal biopsy, which revealed morphological changes of focal, segmental glomerular sclerosis. Subsequently, the child underwent renal transplantation with complete resolution of symptoms and abnormal metabolic findings. This observation suggests that extrarenal factors were not responsible for the development of Bartter's syndrome in this child.
点击下载:
PDF
(521KB)
返 回