Membranoproliferative Glomerulonephritis Associated with Chronic Hepatitis B in Adults: Pathogenetic Role of HBsAg
作者:
Hiroyuki Iida,
Kiyoshi Izumino,
Mitsuhiro Asaka,
Tomoki Kameyama,
Masanobu Takata,
Yasuji Mizumura,
Shigetake Sasayama,
期刊:
American Journal of Nephrology
(Karger Available online 1987)
卷期:
Volume 7,
issue 4
页码: 319-324
ISSN:0250-8095
年代: 1987
DOI:10.1159/000167494
出版商: S. Karger AG
关键词: HB virus-associated glomerulonephritis;Membranoproliferative glomerulonephritis;Chronic hepatitis B;HbsAg;HBeAg
数据来源: Karger
摘要:
Two adult cases of membranoproliferative glomerulonephritis (MPGN) associated with chronic hepatitis B were reported. Serum HBsAg, HBeAg and anti-HBc were positive. Glomerular changes were essentially the same in both patients and consistent with MPGN type III. Immunofluorescence microscopy revealed diffuse granular and lumpy deposits of IgG, IgA, IgM, C1q and C3 along glomerular capillary walls and in mesangial areas. Granular deposition of HBsAg was observed along capillary walls and in mesangial areas, and the staining patterns were similar to those of immunoglobulins and complements in both patients. Glomerular deposition of HBeAg, however, was negative in one case, and only slight and segmental in the other case. These findings suggest that HBsAg rather than HBeAg may play a role in the pathogenesis of MPGN associated with hepatitis B virus infection in adults.
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