Migration from plasticized films into foods. 6. Hydrolysis of polymeric plasticizers under simulated gastric and intestinal conditions
作者:
Laurence Castle,
Janet Nichol,
John Gilbert,
期刊:
Food Additives & Contaminants
(Taylor Available online 1993)
卷期:
Volume 10,
issue 5
页码: 523-529
ISSN:0265-203X
年代: 1993
DOI:10.1080/02652039309374175
出版商: Taylor & Francis Group
关键词: polymeric plasticizer;ingestion;poly(butylene adipate);poly(propylene adipate);gastric and intestinal hydrolysis
数据来源: Taylor
摘要:
The polymeric plasticizers poly(butylene adipate) and poly(propylene adipate), and a low molecular weight oligomer fraction from each, were exposedin vitroto simulated gastric and intestinal hydrolysis in order to study their likely fate after ingestion of foods contaminated by migration from plastics packaging. Analysis for loss of the parent compounds indicated that partial hydrolysis occurred under simulated gastric conditions, with the low molecular weight oligomers being the most susceptible. Analysis for one of the starting materials, adipic acid, revealed however that the hydrolysis did not result in a significant conversion to free monomer under either simulated gastric or intestinal conditions. This is explained on the basis of partial hydrolysis of the plasticizers to smaller oligomer units but with the more resistant ester linkages resisting complete breakdown to monomer.
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