New Thoughts on Resistance to Chemotherapy
作者:
GoldieJames H.,
期刊:
Hospital Practice
(Taylor Available online 1983)
卷期:
Volume 18,
issue 5
页码: 165-177
ISSN:2154-8331
年代: 1983
DOI:10.1080/21548331.1983.11702548
出版商: Taylor&Francis
数据来源: Taylor
摘要:
Kinetic theories of tumor growth do not appear to provide adequate explanations for treatment failure in cancer. It is proposed that drug resistance results from somatic mutations in tumor cell populations and that“front-loaded”first-line treatment strategy with as many effective agents as possible, in the highest dosages possible, represents the clinician's best approach.
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