Clinical Pharmacokinetics of Prazosin - 1985
作者:
John Vincent,
Peter A. Meredith,
John L. Reid,
Henry L. Elliott,
Peter C. Rubin,
期刊:
Clinical Pharmacokinetics
(ADIS Available online 1985)
卷期:
Volume 10,
issue 2
页码: 144-154
ISSN:0312-5963
年代: 1985
出版商: ADIS
数据来源: ADIS
摘要:
Prazosin is a selective &agr;1-adrenoceptor antagonist which is useful alone or in combination for the treatment of hypertension and heart failure. Unlike many other antihypertensive drugs, the action of prazosin appears to be closely related to its concentration in plasma or whole blood. Prazosin is variably absorbed, is subject to first-pass metabolism, and is eliminated almost entirely as metabolites of much lower hypotensive activity than the parent drug. Prazosin is highly bound to plasma and tissue proteins.The influences of renal, hepatic and cardiac disease on the disposition of prazosin are reviewed, as are the effects of pregnancy and ageing. The optimum use of prazosin in clinical practice depends on an understanding of the pharmacokinetic properties of the drug.
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