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Phase II Study of Continuous Venous Infusion of 5-Fluorouracil in Advanced Pancreatic Cancer

 

作者: Hisao Tajiri,   Masayoshi Yoshimori,   Nobuo Okazaki,   Makoto Miyaji,  

 

期刊: Oncology  (Karger Available online 1991)
卷期: Volume 48, issue 1  

页码: 18-21

 

ISSN:0030-2414

 

年代: 1991

 

DOI:10.1159/000226887

 

出版商: S. Karger AG

 

关键词: Pancreatic cancer;Continuous venous infusion;5-Fluorouracil

 

数据来源: Karger

 

摘要:

Continuous venous infusion of 5-fluorouracil (5FU) was investigated in 18 patients with measurable advanced cancer of the pancreas. 5FU was given for 7 days in a dose of 500 mg/m2 by continuous venous infusion over a 24-hour period and then followed by a dose of 170 mg/m2 for more than 28 days. Ten patients had no change including 1 patient with minor response, and 4 patients had disease progression. Serum CA19-9 levels were measured serially after chemotherapy in 13 of 14 evaluable patients. In 3 of 10 patients who showed high levels before treatment, serum CA19-9 levels were significantly decreasing after treatment.

 

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