Pharmacokinetics of Recombinant Human Erythropoietin in Dialysis Patients after Single and Multiple Subcutaneous Administrations
作者:
D. Kampf,
K.U. Eckardt,
H.C. Fischer,
C. Schmalisch,
B. Ehmer,
M. Schostak,
期刊:
Nephron
(Karger Available online 1992)
卷期:
Volume 61,
issue 4
页码: 393-398
ISSN:1660-8151
年代: 1992
DOI:10.1159/000186955
出版商: S. Karger AG
关键词: Anemia;Renal failure;Erythropoietin;Pharmacokinetics;Intravenous administration;Subcutaneous administration
数据来源: Karger
摘要:
The pharmacokinetics of recombinant human erythropoietin (rhEPO) were evaluated after single intravenous and single subcutaneous administration of 40 U/kg to 8 patients with dialysis treatment. All patients suffered from renal anemia with a hematocrit ≤ 24% and were treated with 40 U/kg rhEPO subcutaneously, three times a week for 6 weeks. At the end of the treatment period, kinetics of rhEPO were repeated. After the initial subcutaneous rhEPO dose, the following results were obtained: maximum plasma concentration 39.5 (26.7-56.9) U/l, area under the curve (AUC) 1,122 (582-3,220) U · h · 1-1 and terminal half-life 13.2 (2.6-53.1) h. The corresponding data after multiple rhEPO doses were: maximum rhEPO plasma concentration 26.3 (9.4–49.1) U/l, AUC 724 (407–1,464) U·h·H and terminal half-life 14.2 (3.5-24.4) h. There were no statistical significant differences between the two investigations. From the present study, it can be concluded that after a treatment period of 6 weeks with multiple subcutaneous rhEPO doses, rhEPO absorption as well as rhEPO elimination are
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