Dehydration Selectively Increases Dopamine Synthesis in Tuberohypophyseal Dopaminergic Neurons
作者:
R.H. Alper,
K.T. Demarest,
K.E. Moore,
期刊:
Neuroendocrinology
(Karger Available online 1980)
卷期:
Volume 31,
issue 2
页码: 112-115
ISSN:0028-3835
年代: 1980
DOI:10.1159/000123060
出版商: S. Karger AG
关键词: Dehydration;Tuberohypophyseal nerves;Dopamine
数据来源: Karger
摘要:
The concentration of dopamine (DA) and the accumulation of DOPA following the administration of a decarboxylase inhibitor were determined in the rat striatum, median eminence and posterior pituitary, regions containing terminals of nigrostriatal, tuberoinfundibular and tuberohypophyseal DA nerves, respectively. Severe dehydration (2 days water deprivation followed by 3 days of 2% NaCI substituted for drinking water) incressed the concentration of DA in the posterior pituitary but not in the striatum or median eminence. Less severe dehydration caused by 2 or 3 days of water deprivation did not alter steady state concentrations of DA, but increased DOPA accumulation, an index of DA nerve activity, only in the posterior pituitary. Food deprivation for 3 days did not alter DOPA accumulation in the posterior pituitary. These results suggest that dehydration selectively activates the tuberohypophyseal DA neuronal system in the rat.
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