Carcinogenic Effect of Force-Feeding an Extract of Black Pepper(Piper nigrum)in Egyptian Toads(Bufo regularis)
作者:
M.M. El-Mofty,
V.V. Khudoley,
M.H. Shwaireb,
期刊:
Oncology
(Karger Available online 1991)
卷期:
Volume 48,
issue 4
页码: 347-350
ISSN:0030-2414
年代: 1991
DOI:10.1159/000226955
出版商: S. Karger AG
关键词: Bufo regularis;Black pepper extract;Fibrosarcoma;Hepatocellular carcinoma;Lymphosarcoma;Metastases
数据来源: Karger
摘要:
50 male and 50 female Bufo regularis were treated, by force-feeding, with an extract of black pepper, at a dose level of 2 mg, 3 times a week for 5 months. The first tumors appeared after 2 months. Liver tumors (hepatocellular carcinomas, lymphosarcomas and fibrosarcomas) were found in 12 males and 18 females. Metastatic deposits of hepatocellular carcinomas were registered in the spleen, kidney, fat body and ovary.
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