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Carcinogenic Effect of Force-Feeding an Extract of Black Pepper(Piper nigrum)in Egyptian Toads(Bufo regularis)

 

作者: M.M. El-Mofty,   V.V. Khudoley,   M.H. Shwaireb,  

 

期刊: Oncology  (Karger Available online 1991)
卷期: Volume 48, issue 4  

页码: 347-350

 

ISSN:0030-2414

 

年代: 1991

 

DOI:10.1159/000226955

 

出版商: S. Karger AG

 

关键词: Bufo regularis;Black pepper extract;Fibrosarcoma;Hepatocellular carcinoma;Lymphosarcoma;Metastases

 

数据来源: Karger

 

摘要:

50 male and 50 female Bufo regularis were treated, by force-feeding, with an extract of black pepper, at a dose level of 2 mg, 3 times a week for 5 months. The first tumors appeared after 2 months. Liver tumors (hepatocellular carcinomas, lymphosarcomas and fibrosarcomas) were found in 12 males and 18 females. Metastatic deposits of hepatocellular carcinomas were registered in the spleen, kidney, fat body and ovary.

 

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