Influence of Hydroxyl Radical Scavengers on Platelet Function
作者:
F. Violi,
A. Ghiselli,
L. Iuliano,
C. Alessandri,
C. Cordova,
F. Balsano,
期刊:
Pathophysiology of Haemostasis and Thrombosis
(Karger Available online 1988)
卷期:
Volume 18,
issue 2
页码: 91-98
ISSN:1424-8832
年代: 1988
DOI:10.1159/000215788
出版商: S. Karger AG
关键词: Free radicals;Hydroxyl radical;Platelet;Platelet cyclooxygenase pathway
数据来源: Karger
摘要:
The influence of four hydroxil radical (OH•) scavengers on platelet function was investigated. OH• scavengers inhibited ADP, collagen, arachidonic acid, PAF-induced platelet aggregation, and platelet cyclooxygenase pathway activation, which was studied by evaluating platelet malondialdehyde and serum thromboxane A2 formation. The latter was not affected by superoxide dismutase, catalase, or metal ion chelants such as desferioxamine or DETAPAC. The detection of deoxyribose degradation by stimulated platelets suggested that platelets produce OH•. This study shows that activated platelets produce free radicals and that antioxidant agents such as OH• scavengers inhibit platelet f
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