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Facile Synthesis of (2S,3R)-3-Amino-2-Hydroxycarboxylic Acids, the Key Components of Amastatin and Bestatin

 

作者: Seigo Ishibuchi,   Takeshi Nagatani,   Tadao Ishizuka,   Takehisa Kunieda,  

 

期刊: Natural Product Letters  (Taylor Available online 1992)
卷期: Volume 1, issue 1  

页码: 21-24

 

ISSN:1057-5634

 

年代: 1992

 

DOI:10.1080/10575639208048880

 

出版商: Taylor & Francis Group

 

关键词: 2-Oxazolidinone;Amastatin;Bestatin;(2S,3R)-3-Amino-2-hydroxy-5-methylhexanoic acid;(2S,3R)-3-Amino-2-hydroxy-4-phenylbutanoic acid

 

数据来源: Taylor

 

摘要:

The title amino acids, (2S,3R)-3-amino-2-hydroxy-5-methyl-hexanoic acid (AHMHA) and (2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid (AHPBA), are stereoselectively prepared from (4R,5R)-5-allyl-4-methoxy-2-oxazolidinone which is readily accessible from the previously reported chiral synthon, (4R,5R)-5-phenylseleno-4-methoxy-2-oxazolidinone.

 

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