Facile Synthesis of (2S,3R)-3-Amino-2-Hydroxycarboxylic Acids, the Key Components of Amastatin and Bestatin
作者:
Seigo Ishibuchi,
Takeshi Nagatani,
Tadao Ishizuka,
Takehisa Kunieda,
期刊:
Natural Product Letters
(Taylor Available online 1992)
卷期:
Volume 1,
issue 1
页码: 21-24
ISSN:1057-5634
年代: 1992
DOI:10.1080/10575639208048880
出版商: Taylor & Francis Group
关键词: 2-Oxazolidinone;Amastatin;Bestatin;(2S,3R)-3-Amino-2-hydroxy-5-methylhexanoic acid;(2S,3R)-3-Amino-2-hydroxy-4-phenylbutanoic acid
数据来源: Taylor
摘要:
The title amino acids, (2S,3R)-3-amino-2-hydroxy-5-methyl-hexanoic acid (AHMHA) and (2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid (AHPBA), are stereoselectively prepared from (4R,5R)-5-allyl-4-methoxy-2-oxazolidinone which is readily accessible from the previously reported chiral synthon, (4R,5R)-5-phenylseleno-4-methoxy-2-oxazolidinone.
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