Pharmacokinetic‐pharmacodynamic modeling of caffeine: Tolerance to pressor effects
作者:
Jun Shi,
Neal L Benowitz,
Charles P Denaro,
Lewis B Sheiner,
期刊:
Clinical Pharmacology&Therapeutics
(WILEY Available online 1993)
卷期:
Volume 53,
issue 1
页码: 6-14
ISSN:0009-9236
年代: 1993
DOI:10.1038/clpt.1993.3
数据来源: WILEY
摘要:
We propose a parametric pharmacokinetic‐pharmacodynamic model for caffeine that quantifies the development of tolerance to the pressor effect of the drug and characterizes the mean behavior and inter‐individual variation of both pharmacokinetics and pressor effect. Our study in a small group of subjects indicates that acute tolerance develops to the pressor effect of caffeine and that both the pressor effect and tolerance occur after some time delay relative to changes in plasma caffeine concentration. The half‐life of equilibration of effect with plasma caffeine concentration is about 20 minutes. The half‐life of development and regression of tolerance is estimated to be about 1 hour, and the model suggests that tolerance, at its fullest, causes more than a 90% reduction of initial (nontolerant) effect. Whereas tolerance to the pressor effect of caffeine develops in habitual coffee drinkers, the pressor response is regained after relatively brief periods of abstinence. Because of the rapid development and regression of tolerance, the pressor response to caffeine depends on how much caffeine is consumed, the schedule of consumption, and the elimination half‐life of caffeine.Clinical Pharmacology and Therapeutics(1993)53,6–14; doi:10.1038
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