In Vivo Hematological Effects of Seven Days of rhlL‐6 in Neonatal Rats*
作者:
Mitchell Cairo,
J. Plunkett,
Steven Clark,
Carmella van de Ven,
期刊:
American Journal of Pediatric Hematology/Oncology
(OVID Available online 1992)
卷期:
Volume 14,
issue 1
页码: 44-47
ISSN:0192-8562
年代: 1992
出版商: OVID
关键词: Interleukin 6;Hematopoiesis;Neonates
数据来源: OVID
摘要:
Interleukin 6 (IL-6) has been demonstrated to possess a variety of biological and immunological functional properties. Recently, Interleukin 6 has been shown to stimulate in vitro fetal hematopoiesis. In the present study, we investigated the effects of 7 days of rhlL-6 on newborn rat in vivo myelopoiesis. Sprague-Dawley newborn rats (<24 h old) were injected (intraperitoneally) daily for 7 days with either rhlL-6 or PBS/BSA. RhIL-6 induced a mild but significant increase in the peripheral neutrophil count on day 1 (P < 0.02), but had no significant sustained effects during the remaining 7 days of administration. Additionally, rhIL-6 had no significant effect on the bone marrow neutrophil proliferative pool, neutrophil storage pool, the liver/spleen neutrophil storage pool and neutrophil proliferative pools. Although rhlL-6 induced a significant increase in the day 1 platelet count (p < 0.03), it failed to induce a sustained significant increase in the platelet count during the remaining 7 days of administration. RhIL-6 also failed to induce any change in the circulating hematocrit during the 7 days of administration. This study suggests that rhlL-6 failed to induce a significant and sustained increase in the peripheral neutrophil count or platelet count during in vivo administration in neonatal rats. Although rhlL-6 may possess additional immunomodulating effects in the newborn, this 7-day study of rhlL-6 failed to demonstrate any induction of neonatal peripheral neutrophilia or modulation of neonatal myeloid proliferation.
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