Characterization of the Mouse PDGF A-Chain Gene. Evolutionary Conservation of Gene Structure, Nucleotide Sequence and Alternative Splicing
作者:
RorsmanFredrik,
BetsholtzChrister,
期刊:
Growth Factors
(Taylor Available online 1992)
卷期:
Volume 6,
issue 4
页码: 303-313
ISSN:0897-7194
年代: 1992
DOI:10.3109/08977199209021542
出版商: Taylor&Francis
关键词: platelet-derived growth factor;gene structure;alternative splicing
数据来源: Taylor
摘要:
AbstractThe mouse platelet-derived growth factor (PDGF) A-chain gene has been structurally characterized and compared with its human counterpart. The organization of the two genes is similar. Both consist of 7 exons spaced by 6 introns of corresponding sizes. As in the human gene, exon 6 encodes a sequence which is alternatively spliced. When present, it codes for an alternative C-terminus of the A-chain. In intron 5, conserved stretches of nucleotides, potentially involved in the regulation of the alternative splicing, are identified. The untranslated sequences show a high degree of nucleotide sequence identity and several conserved consensus binding sites for transcription factors are identified within the 5′untranslated as well as in the 5′flanking region.
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