Polydepsipeptides II: Synthesis and Preliminary Conformational Studies of an Alternating α‐Amino and α‐Hydroxy Acid Polymer
作者:
Murray Goodman,
Chaim Gilon,
Manlio Palumbo,
Richard T. Ingwall,
期刊:
Israel Journal of Chemistry
(WILEY Available online 1974)
卷期:
Volume 12,
issue 1‐2
页码: 67-77
ISSN:0021-2148
年代: 1974
DOI:10.1002/ijch.197400008
出版商: WILEY‐VCH Verlag
数据来源: WILEY
摘要:
AbstractAn alternating high‐molecular‐weight polymer of L‐valine and L‐lactic acid was synthesized in the solid state. Results from circular dichroism (CD) and nuclear magnetic resonance (NMR) spectra indicate that these polymers are helical in helicogenic solvents such as chloroform and trifluoroethanol (TFE). The conformational analysis is extended to include semi‐empirical energy calculations for alternating α‐amino and α‐hydroxy acid polymers. Preliminary calculations based on depsipeptides from L‐alanine and L‐lactic
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