Oxytetracyline hydrochloride (OTC) degraded in brood nest honey and surplus honey by 4 weeks after cessation of medication of colonies of honey bees,Apis melliferaL., with sugar dusts or syrup sprays. No OTC residues were found in either brood nest honey or surplus honey from colonies treated with 2 antibiotic extender patties, nor in larvae from colonies treated by any of the 3 methods.