La Neuropathie Du Systeme Autonome: Une Complication Meconnue Du Diabete Sucre Analyse D’Une Population De 61 Diabetiques
作者:
CharlesS.,
SibilleY.,
BuysschaertM.,
KetelslegersJ.M.,
LambertA.E.,
期刊:
Acta Clinica Belgica
(Taylor Available online 1983)
卷期:
Volume 38,
issue 2
页码: 95-101
ISSN:1784-3286
年代: 1983
DOI:10.1080/22953337.1983.11718912
出版商: Taylor&Francis
数据来源: Taylor
摘要:
SummaryDiabetic autonomic neuropathy is a poorly defi ned neurologic entity with morbid and occasional lethal consequences. Cardiovascular effects of the diabetic autonomic neuropathy may include resting tachycardia, postural hypotension and painless myocardial infarction. The involvement of cardiovascular reflexes (beat-to-beat variation during breathing of Valsalva manoeuvre) assesses a cardiac parasympathetic dysfunction.The occurrence of a postural hypotension implies an orthosympathetic damage. We analysed the incidence of autonomic neuropathy in a group of totally insulindependent diabetic patients (mean circadian C peptide level: 0.04 + 0.003 pmol/ml, mean±SEM) and in a group of diabetic patients, with a residual insulin secretion (mean circadian C peptide level: 0.80±0.09 pmol/ml). 44 % of all the patients had up to 4 cardiovascular abnormal tests.Postural hypotension was observed in 11 % of the subjects. We found a significative correlation between the autonomic neuropathy and the duration of diabetes in subjects of group I (p<0.01). No correlation between autonomic neuropathy and C peptide level or mean glycosylated hemoglobin was observed. The high incidence of autonomic neuropathy and the poor prognosis of this diabetic complication justifies its systematic research in all type I and type II diabetic patients.
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