Determination of Kt/V and Protein Catabolic Rate Using Pre- and Postdialysis Blood Urea Nitrogen Concentrations
作者:
Toru Shinzato,
Shigeru Nakai,
Yoshiro Fujita,
Ichiro Takai,
Eiroyuki Morita,
Kazunori Nakane,
Kenji Maeda,
期刊:
Nephron
(Karger Available online 1994)
卷期:
Volume 67,
issue 3
页码: 280-290
ISSN:1660-8151
年代: 1994
DOI:10.1159/000187980
出版商: S. Karger AG
关键词: Protein catabolic rate;Kt/V;Hemodialysis;Urea kinetic modeling;Urea;Uremia
数据来源: Karger
摘要:
We developed a new urea kinetic method for simultaneous determination of the Kt/V and protein catabolic rate (PCR) only from blood urea nitrogen (BUN) concentrations before and after a single dialysis session. Using this method, the parameters were calculated within 1.5 s even when a hand-held computer with a low central processing capacity is used. The total amount of urea eliminated during three dialysis sessions in 1 week is assumed to be equal to urea volume (Gw) generated over a 1-week period (Tw): Gw = G × Tw = K T∫0 C1dt+ T∫0 C2dt+ T∫0 C3dt). Here, G is the generation rate, K is the dialyzer urea clearance, T is the dialysis time and Q, C2 and C3 are BUN during the respective dialysis session. If this equation and the equation expressing the urea kinetics during a single dialysis session are solved together, we have a solution for Kt/V and G. The thus-obtained Kt/V and G are corrected using the change in body weight. The corrected Kt/V showed a good correspondence with the parameter calculated with the classical method, and the midweek PCR derived from G determined by the present method being equivalent to the PCR averaged for a 1-week period determined by the classical m
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