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Cross–reactive antigenic determinants present on differentPlasmodium falciparumblood–stage antigens

 

作者: DENISE MATTEI,   KLAVS BERZINS,   MATS WAHLGREN,   RACHANEE UDOMSANGPETCH,   PETER PERLMANN,   HANS WERNER GRIESSER,   ARTUR SCHERF,   BENNO MÜJLLER–HILL,   SERGE BONNEFOY,   MICHELINE GUILLOTTE,   GORDON LANGSLEY,   LUIZ PEREIRA DA SILVA,   ODILE MERCEREAU–PUIJALON,  

 

期刊: Parasite Immunology  （WILEY Available online 1989）
卷期: Volume 11, issue 1  

页码: 15-29

 

ISSN:0141-9838

 

年代: 1989

 

DOI:10.1111/j.1365-3024.1989.tb00645.x

 

出版商: Blackwell Publishing Ltd

 

关键词: Plasmodium falciparum;malaria;cross–reactivity

 

数据来源: WILEY

 

摘要:

SummaryA gene encoding a previously undescribed antigen ofPlasmodium falciparumhas been isolated from a genomic expression library by use of a pool of human immune sera. Northern blot analysis indicated that the gene is expressed at the late stages of the intra–erythrocytic cycle. This antigen, 332, contains a series of degenerated amino acid repeats. Human antibodies affinity–purified on the 332 recombinant antigen reacted with a family of parasite proteins that are products of different genes. We identified antigens 11.1 and Pf 155–RESA as members of this family and confirmed, using a human monoclonal antibody, the presence of cross–reacting determinants. The sequences of these antigens also share some structural homologies. The significance of this family of blood–stage antigens is

 

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