Lymphatic Transport of Cholesterol from Exogenous and Biliary Origins in Nonfasting Rats After Intraduodenal Infusions of Triolein
作者:
Danièle Reisser,
Marguerite-Marie Boutillon,
Jacqueline Clément,
期刊:
Annals of Nutrition and Metabolism
(Karger Available online 1983)
卷期:
Volume 27,
issue 3
页码: 252-260
ISSN:0250-6807
年代: 1983
DOI:10.1159/000176667
出版商: S. Karger AG
关键词: Exogenous cholesterol absorption;Biliary cholesterol absorption;Triolein;Rat lymph
数据来源: Karger
摘要:
Labelled thoracic-duct lymph was collected from nonfasting rats with a bile fistula after simultaneous intraduodenal infusions of bile labelled with [1–2 3H] cholesterol and a nutritive mixture containing [4–14C] cholesterol. The gastrointestinal tract, feces, chylomicrons and infranatants were analysed. Both biliary and exogenous cholesterol were absorbed by lymphatic way but the recovery of 3H labelling in total lymph was markedly higher than that of 14C activity. This fact might be due to different rates of cholesterol exchanges from the two origins with the nonlabelled cholesterol present in the enterocytes and further exchanges of the enterocytes cholesterol with plasma cholesterol. Most of radioactivity was detected in chylomicrons. The relative [3H] and [14C] cholesterol specific activities were always low; thus when a little exogenous cholesterol is brought the major part of lymph cholesterol had an endogenous – other than biliary –
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