Novel cross‐reactive epitopes on asexual blood stage antigens of Plasmodium falciparum
作者:
RANJAN RAMASAMY,
H. MARIO GEYSEN,
期刊:
Parasite Immunology
(WILEY Available online 1990)
卷期:
Volume 12,
issue 4‐5
页码: 457-471
ISSN:0141-9838
年代: 1990
DOI:10.1111/j.1365-3024.1990.tb00981.x
出版商: Blackwell Publishing Ltd
关键词: antigenic cross‐reactions;epitopes;IgM;immunity;malaria;monoclonal antibody;Plasmodium falciparum;protein structure
数据来源: WILEY
摘要:
SummaryAn IgM monoclonal antibody that reacts with the merozoite membrane and internal merozoite antigens was shown to recognize several previously characterized asexual blood stage antigens ofPlasmodium falciparumas well as new antigens. Among the reactive antigens identified were FIRA, GYMSSA, RESA and the S‐antigen. Analysis of the cross‐reactions between FIRA and GYMSSA by epitope scanning was performed. The most reactive peptides in GYMSSA had the common sequence STNS. The cross‐reactive epitopes in FIRA could, in many cases, be explained by the results of a replacement net analysis performed on the STNS epitope. It is proposed that the cross‐reactive epitopes, which in several cases have no obvious linear homology but possess high S, T and N content, may be present as loops or coils on the surface of the mo
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