This article describes the Lead Teacher Component of the NSF‐funded State Systemic Initiative, Virginia's Quality Education in Science and Technology (V‐QUEST). Part of V‐QUEST focuses on the integration of mathematics and science in elementary and middle schools. Some recent research findings and recommendations which informed the planning and decisions are cited. The article describes the guiding principles, objectives, strategies, and agencies involved in the project. An outline of how the integration of mathematics and science elements were developed is provided and some preliminary outcomes are catalogued. An important feature of the systemic project is the manner through which it includes a wide range of individuals and organizations concerned with education in all the planning and implementation p