Association of primary sclerosing cholangitis, thymoma and hypogammaglobulinemia
作者:
Ryoji Yoshioka,
Yukio Sato,
Atsuko Kogure,
Hiromasa Ohira,
Tohru Takagi,
Masahito Kuroda,
Masayuki Miyata,
Katsutoshi Obara,
Tomoe Nishimaki,
Reiji Kasukawa,
期刊:
Liver
(WILEY Available online 1995)
卷期:
Volume 15,
issue 1
页码: 53-55
ISSN:0106-9543
年代: 1995
DOI:10.1111/j.1600-0676.1995.tb00107.x
出版商: Blackwell Publishing Ltd
关键词: immunodeficiency;hypogammaglobulinemia;primary sclerosing cholangitis;thymoma
数据来源: WILEY
摘要:
A 64‐year‐old Japanese woman with thymoma has been suffering from diarrhea and increased alkaline phosphatase levels without jaundice. Her serum immunoglobulin levels of IgM and IgG were less than half of the normal levels, with an increase in CD8 (suppressor/cytotoxic) T cell percentage and a decrease in CD4 (helper) T cell percentage, resulting in a lower CD4/CD8 ratio of 0.31. These immunological features are in accordance with those of hypogammaglobulinemia complicating thymoma. Cholangiography and a liver biopsy specimen disclosed the presence of primary sclerosing cholangitis (PSC). PSC has been recognized in various immunodeficiency syndromes and this case shows that thymoma complicated by hypogammaglobulinemia is associated with
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