Effects of various anesthetic and autonomic drugs on refraction in monkeys
作者:
CrawfordKathryn,
GabeltB'Ann True,
KaufmanPaul L.,
BitoLaszlo Z.,
期刊:
Current Eye Research
(Taylor Available online 1990)
卷期:
Volume 9,
issue 6
页码: 525-532
ISSN:0271-3683
年代: 1990
DOI:10.3109/02713689008999592
出版商: Taylor&Francis
数据来源: Taylor
摘要:
Resting refractive correction in ketamine-, pentobarbital-, or halothane-anesthetized rhesus and cynomolgus monkeys was∼1–3 diopters myopic, with little difference under the various anesthetic regimens. Topical cyclopentolate or atropine, or systemic hexamethonium eliminated much of the myopia, while epinephrine, phenylephrine and thymoxamine had little effect. Anesthesia-induced myopia in monkeys thus seems comparable to tonic accommodation (“night myopia”) in the human. Accommodation induced by electrical stimulation of the Edinger-Westphal nucleus averaged∼50% less under halothane than under pentobarbital, possibly due to halothane-induced systemic arterial hypotension.
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