Modulation of Phenotype and Cytoskeleton Architecture by lnterleukin-1 Alpha in Human Osteoblast-Like Cells in vitro
作者:
M. Bodo,
T. Baroni,
M. Calvitti,
F. Carinci,
N. Arena,
G. Venti,
期刊:
Cells Tissues Organs
(Karger Available online 1992)
卷期:
Volume 145,
issue 2
页码: 156-161
ISSN:1422-6405
年代: 1992
DOI:10.1159/000147358
出版商: S. Karger AG
关键词: Interleukin-1α;Osteoblast-like cells;Morphology;Cytoskeleton;Fibronectin
数据来源: Karger
摘要:
Interleukin-1α, a growth factor produced by macrophages as well as many other types of cells, is able to modulate biosynthetic activities in bone cells. In this work, the authors show that the administration of interleukin-1α to osteoblas-like cells in vitro induces a marked change in cell morphology, which becomes dendritic, with a smaller cellular body and numerous prolongations. The morphological changes are also accompanied by an alterated expression in the pattern of cytoskeleton protein
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