Pharmacokinetics of Multiple Oral Dose Divalproex Sodium after Intravenous Loading Dose Administration in Healthy Volunteers
作者:
J.H. Cavanaugh,
Z. Hussein,
J. Lamm,
G.R. Granneman,
期刊:
Drug Investigation
(ADIS Available online 1994)
卷期:
Volume 7,
issue 1
页码: 1-7
ISSN:0114-2402
年代: 1994
出版商: ADIS
数据来源: ADIS
摘要:
A randomised study was conducted in healthy male volunteers to assess the pharmacokinetics of valproate after multiple 500mg (every 8 hours) or 250mg (every 6 hours) doses commencing 1 to 3 hours following an intravenous 1000mg loading dose administered over 10 minutes. Multiple blood samples were collected throughout the 73- to 75-hour study period and plasma valproate concentrations were quantified using a gas chromatographic technique. All 3 regimens produced near steady-state trough plasma concentrations generally above 50 mg/L throughout the first study day. By the morning of day 2, pseudo-steady-state conditions had been established. Overall, an intravenous 1000mg loading dose of valproic acid followed within 3 hours by oral regimens of divalproex sodium 500mg every 8 hours or 250mg every 6 hours appears to be an acceptable approach to rapidly achieve therapeutic concentrations with steady-state trough plasma concentrations above 50 mg/L.
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