VAB-6 Chemotherapy Causes Spurious Elevation of Alpha-Fetoprotein Associated with Liver Dysfunctions
作者:
Shuichi Hida,
Kazuo Nishimura,
Yasunori Nishio,
Kenji Oishi,
Hideo Takeuchi,
Osamu Yoshida,
期刊:
Urologia Internationalis
(Karger Available online 1991)
卷期:
Volume 46,
issue 1
页码: 1-5
ISSN:0042-1138
年代: 1991
DOI:10.1159/000281762
出版商: S. Karger AG
关键词: Alpha-fetoprotein;False positive;Hepatic dysfunction;VAB-6 chemotherapy;Testicular cancer
数据来源: Karger
摘要:
In order to elucidate the mechanism of elevation of α-fetoprotein (AFP) which we often observed during VAB-6 chemotherapy, we analyzed sequential changes of AFP, liver enzymes and bilirubin in 10 patients with evaluable disseminated testicular cancer who were treated with VAB-6 chemotherapy. None of the patients had previous liver disease or hepatic involvement. During the early phase of each course of chemotherapy, AFP showed a temporary elevation associated with reversible increase in liver enzymes and bilirubin. These changes returned to normal before the next course of chemotherapy. In each patient, marked tumor regression occurred as a result of VAB-6 chemotherapy. Nine of the 10 patients remain free of disease after treatment. We conclude that during VAB-6 chemotherapy, a temporary elevation of AFP is common, associated with reversible liver dysfunctions, and that this spurious elevation of the tumor marker, most likely caused by a heavy dose of cisplatin, should not be interpreted as related treatment failure
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