Genetic Linkage Analysis of Thyroid Autoantibodies
作者:
PrenticeLouise,
PhillipsDavid I. W.,
PremawardhanaL.D.K.E.,
SmithBernard Rees,
期刊:
Autoimmunity
(Taylor Available online 1993)
卷期:
Volume 15,
issue 3
页码: 225-229
ISSN:0891-6934
年代: 1993
DOI:10.3109/08916939309019931
出版商: Taylor&Francis
关键词: Autoimmune thyroid disease;thyroglobulin;thyroid peroxidase autoantibodies;genetic linkage study
数据来源: Taylor
摘要:
Segregation analysis has suggested that the inheritance of thyroid autoantibodies (to thyroglobulin and to thyroid peroxidase) is a dominant Mendelian trait.In this study we describe an attempt to find the chromosomal location(s) of gene(s) responsible for thyroid autoantibody production. We have examined a number of restriction length polymorphisms (RFLPs) and highly polymorphic markers (mini- and microsatellite) for genetic linkage with thyroid autoantibodies using a panel of 16 families with autoimmune thyroid disease. None of the markers used in this study gave evidence of linkage, however minisatellite markers (MSI, MS31, MS32, MS43a, M851, G3) for TPO antibody, minisatellite markers (MSI, MS32, MS43a, MS51, G3) for Tg antibody, and all microsatellite markers used, provided evidence for exclusion of genetic linkage.
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