The Metabolic Basis of Alcohol's Toxicity
作者:
LieberCharles S.,
期刊:
Hospital Practice
(Taylor Available online 1977)
卷期:
Volume 12,
issue 2
页码: 73-80
ISSN:2154-8331
年代: 1977
DOI:10.1080/21548331.1977.11707079
出版商: Taylor&Francis
数据来源: Taylor
摘要:
The mechanisms by which excess alcohol directly damages the liver cells have been elucidated by studies in the baboon, which have shown that inability of the liver's enzyme systems to cope with hydrogen and fat overloads is far more significant in the progression to cirrhosis than any indirect effects of malnutrition. With the appearance of mitochondrial deformation, the process may have reached the stage of irreversibility.
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