Calcium antagonistic effects of terodiline in rabbit aorta and human uterus
作者:
J. R. Østergaard,
K. Østergaard,
K.‐E. Andersson,
L. Sommer,
期刊:
Acta Pharmacologica et Toxicologica
(WILEY Available online 1980)
卷期:
Volume 46,
issue 1
页码: 12-19
ISSN:0001-6683
年代: 1980
DOI:10.1111/j.1600-0773.1980.tb03243.x
出版商: Blackwell Publishing Ltd
关键词: terodiline;calcium antagonism;isolated rabbit aorta;isolated human uterus;45Ca influx
数据来源: WILEY
摘要:
AbstractThe possible calcium antagonistic action of the anti‐anginal drug terodiline was investigated by two experimental techniques. In isolated preparations of rabbit aorta and pregnant human uterus exposed to a calcium‐free medium and then depolarized by potassium, terodiline in concentrations of 4.5–36 μM inhibited contractions produced by cumulative addition of calcium to the extracellular medium. This effect of terodiline could be reversed by high concentrations of calcium. Within the same concentration range, terodiline also reduced potassium‐induced45Ca influx in isolated aorta without affecting calcium efflux. It is suggested that terodiline, which structurally has similarities to prenylamine and fendiline, like these drugs can be classified as a calcium an
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