Synthesis of Novel 1,3,5‐Trisubstituted Pyrazoles as Potential Hypoglycemic Agents
作者:
Hassan M. Mokhtar,
S. M. El‐Khawass,
期刊:
Journal of the Chinese Chemical Society
(WILEY Available online 1988)
卷期:
Volume 35,
issue 1
页码: 57-62
ISSN:0009-4536
年代: 1988
DOI:10.1002/jccs.198800009
出版商: WILEY‐VCH Verlag
关键词: Hypoglycemic agent;pyrazole
数据来源: WILEY
摘要:
AbstractA novel series of 1,3,5‐trisubstituted pyrazoles was synthesized. Thus, ethyl 2,4‐dioxo‐6‐phenylhex‐5‐enoate (I) was condensed with phenylhydrazine to afford 3‐ethoxycarbonyl‐1‐phenyl‐5‐styrylpyrazole (II) which on fusion with hydrazine hydrate gave the corresponding acid hydrazide (III). Reaction of III with the appropriate isothiocyanate yielded the disubstituted thiosemicarbazides (IVa‐e) which were cyclized into thiotriazoles (Va‐e), thiadiazoles (Vla‐e) and oxadiazoles (VIIa‐). The structure of the newly synthesized compounds was elucidated by elemental a
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