Anti-TNF-alpha and Pentoxifylline for Prophylaxis of aGvHD in Murine Allogeneic Bone Marrow Transplantation
作者:
E. Holler,
S. Thierfelder,
U. Behrends,
L. Daum,
R. Hintermeíer-Knabe,
H.J. Kolb,
J. Kempeni,
W. Wilmanns,
期刊:
Onkologie
(Karger Available online 1992)
卷期:
Volume 15,
issue 1
页码: 31-35
ISSN:0378-584X
年代: 1992
DOI:10.1159/000217329
出版商: S. Karger GmbH
关键词: Allogeneic bone marrow transplantation;Acute graft-versus-host disease;TNFalpha;Anti-TNF-antibodies;Pentoxifylline
数据来源: Karger
摘要:
Clinical studies analyzing sequential serum levels suggest pathophysiological involvement of Tumor-Necrosis-Factor-alpha (TNFa) in acute graft-versus-host disease (aGvHD) and endothelial complications following allogeneic bone marrow transplantation (BMT). For further investigation of the role of TNFa in aGvHD a neutralizing rb-anti-ms-TNFalpha antibody or pentoxifylline (PTX) as an inhibitor of TNFa-transcription were injected in lethally irradiated mice before or following transplantation of semi- or fully allogeneic bone marrow and various T-cell doses. Prophylactic application of anti-TNFa either prior to irradiation and BMT (p < .05) or at weekly intervals from d7 until d35 (p < .Ol) significantly reduced aGvHD-related mortality and cachexia, when low doses of semiallogeneic T cells were used for induction of aGvHD. Under these conditions, only a marginal protective effect could be obtained by long term application of PTX. In addition, aGvHD induced by high doses of T cells or by transfer of fully allogeneic T lymphocytes could not be prevented by anti-TNFa. These results further indicate that neutralization of TNFa might be helpful as an additive strategy for prevention of aGvHD especially in HLA-identical BMT.
点击下载:
PDF
(1787KB)
返 回