Mitotic arrest by benzimidazole analogs in human lymphocyte cultures
作者:
Henry E. Holden,
Paula A. Crider,
Margitta G. Wahrenburg,
期刊:
Environmental Mutagenesis
(WILEY Available online 1980)
卷期:
Volume 2,
issue 1
页码: 67-73
ISSN:0192-2521
年代: 1980
DOI:10.1002/em.2860020110
出版商: Wiley Subscription Services, Inc., A Wiley Company
关键词: benzimidazole;mitotic arrest;spindle disruption
数据来源: WILEY
摘要:
AbstractPublished reports have suggested the possible association of mutagenic or teratogenic properties of some benzimidazole analogs with induced spindle disruption and consequent mitotic arrest. Studies were conducted to explore this correlation. Seven benzimidazole analogs were evaluated in a human lymphocyte system for ability to block mitosis at metaphase. Confirming the previously reported results, four compounds, mebendazole, parbendazole, cambendazole, and fenbendazole, caused metaphase accumulation, which we found to be dose and time‐related. Minimum effective dose for mebendazole and cambendazole was 10 μg/ml; for parbendazole, 1 μg/ml; and for fenbendazole, 100 μ/ml. The drug‐induced mitotic arrest is qualitatively and quantitatively similar to that produced by colcemid. No activity was observed with three other compounds, benzimidazole, thiabendazole, and oxfendazole when tested at 100 μg/ml. Presence or absence of mitotic effects is correlated with reported teratogenicity with five out of the seven analogs. This suggests some utility of mitotic assessments for predicting teratog
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