Antiepileptic Therapy with Phenytoin: Which Is the Optimum Serum Level?
作者:
B. Weisner,
W. Bernhardt,
期刊:
European Neurology
(Karger Available online 1979)
卷期:
Volume 18,
issue 2
页码: 111-115
ISSN:0014-3022
年代: 1979
DOI:10.1159/000115064
出版商: S. Karger AG
关键词: Grand mal epilepsy;Serum phenytoin;Response curve
数据来源: Karger
摘要:
114 patients suffering from generalized grand mal seizures were treated with phenytoin only. Serum-phenytoin was monitored, and its relation to the frequency of attacks was established in each case, observing steady state periods of at least 3 months’ duration. In a group of 44 patients the reduction in pretreatment frequency of attacks was used to evaluate the drug effect. The probability of attacks followed an exponential function of serum-phenytoin. Curves of equal probability for further attacks were plotted; they may assist in determining the initial regimen. However, the high variability in responsiveness during a serum-phenytoin below 10 mg/l suggested that the effective level has to be determined separately and repeatedly for every single patien
点击下载:
PDF
(602KB)
返 回