Prediction of Maintenance Dose Required to Attain a Desired Drug Concentration at Steady-state From a Single Determination of Concentration After an Initial Dose
作者:
John T. Slattery,
Milo Gibaldi,
Jeffery R. Koup,
期刊:
Clinical Pharmacokinetics
(ADIS Available online 1980)
卷期:
Volume 5,
issue 4
页码: 377-385
ISSN:0312-5963
年代: 1980
出版商: ADIS
数据来源: ADIS
摘要:
Strong correlations have been reported between drug concentrations at steady-state and a single drug concentration determined sometime after an initial dose for lithium, nortriptyline, imipramine, desipramine, choramphenicol and theophylline. The mathematical basis of these relationships suggests that a one point method for predicting steady-state drug concentrations and individual dosing requirements should be widely applicable to most drugs and should be valid for patients having a wide range of drug half-lives.A method is presented for evaluating the optimum time of blood sampling to determine a drug concentration in serum or plasma that best correlates with steady-state levels and for defining the range of drug half-lives beyond which the predictive approach is likely to give poor results.
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