The optical properties of tyrosine‐containing cyclic dipeptides
作者:
Julian W. Snow,
Thomas M. Hooker,
John A. Schellman,
期刊:
Biopolymers
(WILEY Available online 1977)
卷期:
Volume 16,
issue 1
页码: 121-142
ISSN:0006-3525
年代: 1977
DOI:10.1002/bip.1977.360160110
出版商: Wiley Subscription Services, Inc., A Wiley Company
数据来源: WILEY
摘要:
AbstractThe chiroptical properties of the cyclic dipeptidescyclo(L‐alanyl‐L‐tyrosine) andcyclo(L‐tyrosyl‐L‐tyrosine) have been investigated as a function of molecular conformation. Theoretical optical calculations and conformational energy calculations have been carried out as a function of the side‐chain dihedral angles χ1and χ2, and as a function of the angle of fold of the cyclic dipeptide backbone. The results of these theoretical calculations have been compared with experimental circular dichroism (CD) data. Theoretical predictions are in very good agreement with experiment forc(L‐Tyr‐L‐Tyr). Agreement was not quite as good forc(L‐Ala‐L‐Tyr), although the signs of all of the Cotton effects were apparently predicted correctly except for that associated with the lowest ener
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