Phagocytic activity and expression of myeloid‐associated cell surface antigens by blast cells in acute lymphoblastic leukemia
作者:
Ching‐Hon Pui,
Joseph Mirro,
Linda Woodruff,
Tina Motroni,
Sanford Stass,
期刊:
Medical and Pediatric Oncology
(WILEY Available online 1986)
卷期:
Volume 14,
issue 1
页码: 12-16
ISSN:0098-1532
年代: 1986
DOI:10.1002/mpo.2950140104
出版商: Wiley Subscription Services, Inc., A Wiley Company
关键词: phagocytic activity;myeloid‐associated cell surface antigens;acute lymphoblastic leukemia
数据来源: WILEY
摘要:
AbstractThe malignant cells of patients with acute lymphoblastic leukemia (ALL) rarely show phagocytic activity. In this retrospective survey, blasts from 7 of 196 patients with newly diagnosed ALL demonstrated phagocytic activity toward platelets and erythrocytes. The morphology and cytochemical staining properties of the cells were typical of ALL. Immunophenotyes were those of common ALL (CALLA + HLA‐DR + ) for six patients and of pre‐B‐cell ALL (positive cytoplasmic immunoglobulin) for one. However, blast cells from six of the seven patients also reacted with myeloid‐associated monoclonal antibodies (MCS.2 and/or SJ‐D1). The wide overlap in the percentages of blasts expressing CALLA and those expressing myeloid‐associated antigens suggests that some cells possessed both lymphoid‐ and myeloid‐associated surface antigens. By a dual staining technique, two patients tested had blasts expressing antigens of both lineages. Each child achieved a complete remission alter treatment with agents effective for ALL and remains in remission for 13 + to 20 + months. These morphologic and immunologic findings may define a distinct subtype of
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